Calcipotriene 112828-00-9 Vitamin D derivative Dermatological
Payment: T/T, L/C
Product Origin: China
Shipping Port: Beijing/Shanghai/Hangzhou
Production capacity: 1kg/month
Order(MOQ): 1g
Lead Time: 3 Working Days
Storage condition: Stored in cool and dry place, sealed and keep away from light.
Package material:vial, bottle
Package size:1g/vial, 5/vial, 10g/vial, 50g/bottle, 500g/bottle
Safety information: Not dangerous goods
Introduction
Calcipotriol, also known as calcipotriene, is a synthetic derivative of calcitriol, a form of vitamin D. It binds to the VD3 receptor on the cell surface and regulates the synthesis of DNA and keratin in the cell. It can inhibit the excessive proliferation of skin cells (keratinocytes) and induce their differentiation, thereby making psoriatic skin. Abnormal proliferation and differentiation of cells were corrected. At the same time, it regulates the release of cellular inflammatory factors, inhibits inflammatory infiltration and proliferation, and plays an anti-inflammatory role. It is better for the treatment of psoriasis in special areas such as the scalp.
Specification (in house standard)
|
Item |
Specification |
|
Appearance |
White or almost white crystalline powder |
|
Solubility |
Practically insoluble in water, freely soluble in ethanol (96%), slightly soluble in methylene chloride |
|
Identification |
IR: IR chromatograph conforms to the characteristic peak of R.S. |
|
HPLC: HPLC retention time of sample should be concordant with that of reference standard. |
|
|
Water |
Not more than 1.0% |
|
Related substances (HPLC) |
Max. individual impurity: NMT 0.5% |
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Total impurities: NMT 2.5% |
|
|
Assay |
95.5~102.0% |
