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China Manufacturer for Brimonidine Tartrate 70359-46-5 - Orlistat 96829-58-2 Antiobesity Diet supplement – Neore

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China Manufacturer for Brimonidine Tartrate 70359-46-5 - Orlistat 96829-58-2 Antiobesity Diet supplement – Neore Detail:

Payment: T/T, L/C
Product Origin: China
Shipping Port: Beijing/Shanghai/Hangzhou
Production capacity: 800kg/month
Order(MOQ): 25kg
Lead Time: 3 Working Days
Storage condition: Stored in cool, dry place, room temperature.
Package material: drum
Package size: 25kg/drum
Safety information: Not dangerous goods

Orlistat

Introduction

Orlistat is a long-acting and powerful specific gastrointestinal lipase inhibitor. It is white or nearly white powder at room temperature, which insoluble in water, soluble in chloroform, and easily soluble in ethanol. It inactivates the enzyme by forming covalent bonds with the active serine sites of gastric lipase and pancreatic lipase in the stomach and small intestine.

Orlistat is a kind of lipase inhibitor weight-loss drug. It is a hydrated derivative of lipstatin, which can reduce the absorption of food fat and reduce weight. This product has strong and selective inhibition of gastric lipase and pancreatic lipase, has no effect on other digestive enzymes (amylase, trypsin, chymotrypsin) and phospholipase, and does not affect the absorption of carbohydrates, proteins and phospholipids. It inactivates the enzyme mainly through covalent binding with serine residues at the active sites of gastric lipase and pancreatic lipase in the gastrointestinal tract, inhibits the hydrolysis of triacylglycerol, reduces the intake of monoglyceride and free fatty acid, and thus controls body weight. The drug is not absorbed by gastrointestinal tract, and the inhibition of lipase is reversible.

This product also has the function of regulating blood lipids. It can reduce triglyceride and low-density lipoprotein cholesterol in the serum of obese patients and increase the ratio of high-density lipoprotein to low-density lipoprotein.

When orlistat combined with a low calorie diet, it is suitable for the long-term treatment of obese and overweight people, including those who have developed obesity related risk factors. It has long term weight control function such as weight loss, weight maintenance and rebound prevention. The clinical shows obviously that the weight control function is very useful for long term usage when company with meal or after one hour of meal.

Orlistat can reduce the incidence rate of obesity related risk factors and other obesity related diseases, including hypercholesterolemia, type II diabetes, impaired glucose tolerance, hyperinsulinemia, hypertension, and reduce the fat content in organs.

Specification (USP42)

Item

Specification

Identification

HPLC, IR
Specific optical rotation -48.0°~-51.0°
Water content ≤0.2%
Related substances I Orlistat related compound A ≤0.2%
Related substances II Orlistat related compound B ≤0.05%
Related substances III

 

Formylleucine ≤0.2%

Orlistat related compound C ≤0.05%

Orlistat open ring epimer ≤0.2%

D-Leucine orlistat ≤0.2%

Individual unidentified impurity ≤0.1%

Related substances IV

Orlistat related compound D ≤0.2%

Orlistat open ring amide ≤0.1%

Related substances V

Orlistat related compound E ≤0.2%

Total impurities (I to V)

≤1.0%

Residual solvents

Methanol ≤0.3%

EtOAc ≤0.5%

n-Heptane ≤0.5%

Residue on ignition

≤0.1%

Heavy metals as Pb

≤20ppm

Assay by HPLC

98.0%~101.5% (on anhydrous, solvent-free basis)


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We provide good power in high-quality and progress,merchandising,revenue and internet marketing and operation for China Manufacturer for Brimonidine Tartrate 70359-46-5 - Orlistat 96829-58-2 Antiobesity Diet supplement – Neore , The product will supply to all over the world, such as: Iceland, Romania, Morocco, We are trying our best to make more customers happy and satisfied. we sincerely hope to establish a good long-term business relationship with your esteemed company thought this opportunity,based on equal, mutual beneficial and win win business from now till the future.
  • This enterprise in the industry is strong and competitive, advancing with the times and develop sustainable, we are very pleased to have a opportunity to cooperate!
    5 Stars By Liz from Swedish - 2018.06.09 12:42
    The supplier cooperation attitude is very good, encountered various problems, always willing to cooperate with us, to us as the real God.
    5 Stars By Ivy from Swiss - 2017.03.28 16:34