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Factory directly supply 86404-04-8 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore

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Factory directly supply 86404-04-8 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore Detail:

Payment: T/T, L/C
Product Origin: China
Shipping Port: Beijing/Shanghai/Hangzhou
Production capacity: 1kg/month
Order(MOQ): 1g
Lead Time: 3 Working Days
Storage condition: Stored in cool, dry place, room temperature.
Package material: vial, bottle
Package size: 1g/vial, 5/vial, 10g/vial, 50g/bottle, 500g/bottle
Safety information:  UN 2811 6.1/PG 3

Tacrolimus monohydrate

Introduction

Tacrolimus, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. It can be used to treat dry eye syndrome in cats and dogs.

Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, as part of the body’s learned (or adaptive) immune response.

Specification (USP43)

Item

Specification

Appearance

White or almost white crystalline powder

Identification

IR, HPLC

Solubility

Very soluble in methanol, freely soluble in N,N dimethylformamide and in alcohol, practically in soluble in water.

Residue on ignition

≤0.10 %

Organic impurities

 (procedure-2)

Ascomycin 19-epimer ≤0.10 %

Ascomycin ≤0.50 %

Desmethyl tacrolimus ≤0.10 %

Tacrolimus 8-epimer ≤0.15 %

Tacrolimus 8-propyl analog ≤0.15 %

Unknown impurity -I ≤0.10 %

Unknown impurity -II ≤0.10 %

Unknown impurity -III ≤0.10 %

Total impurities ≤1.00 %

Optical rotation (on as is basis)

 (10mg/ml in N,Ndimethylformamide)

-110.0° ~ -115.0°

Water content (by KF)

≤4.0%

Residual solvents (by GC)

Acetone ≤1000ppm (In-house)

Di-isopropyl ether ≤100ppm (In-house)

Ethyl ether ≤5000ppm

Acetonitrile ≤410ppm

Toluene ≤890ppm

Hexane ≤290ppm

Microbial test (in house)

Total aerobic microbial count ≤100cfu/gm

Total yeast and mould count ≤10cfu/gm

Specified organisms (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) should absent

Assay (by HPLC) (on anhydrous and solvent free basis)

98%~102%


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We have the most advanced production equipment, experienced and qualified engineers and workers, recognized quality control systems and a friendly professional sales team pre/after-sales support for Factory directly supply 86404-04-8 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore , The product will supply to all over the world, such as: Bandung, European, Wellington, Be sure to feel cost-free to send us your specs and we are going to respond for you asap. We have got a experienced engineering team to serve for the every single comprehensive needs. Free samples may be sent for yourself personally to know far more facts. So that you can meet your desires, please actually feel cost-free to contact us. You could send us emails and call us straight. Additionally, we welcome visits to our factory from all over the world for much better recognizing of our corporation. nd merchandise. In our trade with merchants of several countries, we often adhere to the principle of equality and mutual advantage. It is our hope to market, by joint efforts, both trade and friendship to our mutual benefit. We look forward to getting your inquiries.
  • Factory equipment is advanced in the industry and the product is fine workmanship, moreover the price is very cheap, value for money!
    5 Stars By Eleanore from Detroit - 2018.11.02 11:11
    Staff is skilled, well-equipped, process is specification, products meet the requirements and delivery is guaranteed, a best partner!
    5 Stars By Stephanie from Provence - 2018.06.21 17:11