Fixed Competitive Price 112828-00-9 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore
Fixed Competitive Price 112828-00-9 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore Detail:
Payment: T/T, L/C
Product Origin: China
Shipping Port: Beijing/Shanghai/Hangzhou
Production capacity: 1kg/month
Order(MOQ): 1g
Lead Time: 3 Working Days
Storage condition: Stored in cool, dry place, room temperature.
Package material: vial, bottle
Package size: 1g/vial, 5/vial, 10g/vial, 50g/bottle, 500g/bottle
Safety information: UN 2811 6.1/PG 3
Introduction
Tacrolimus, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. It can be used to treat dry eye syndrome in cats and dogs.
Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, as part of the body’s learned (or adaptive) immune response.
Specification (USP43)
|
Item |
Specification |
|
Appearance |
White or almost white crystalline powder |
|
Identification |
IR, HPLC |
| Solubility |
Very soluble in methanol, freely soluble in N,N dimethylformamide and in alcohol, practically in soluble in water. |
|
Residue on ignition |
≤0.10 % |
|
Organic impurities (procedure-2) |
Ascomycin 19-epimer ≤0.10 % |
|
Ascomycin ≤0.50 % |
|
|
Desmethyl tacrolimus ≤0.10 % |
|
|
Tacrolimus 8-epimer ≤0.15 % |
|
|
Tacrolimus 8-propyl analog ≤0.15 % |
|
|
Unknown impurity -I ≤0.10 % |
|
|
Unknown impurity -II ≤0.10 % |
|
|
Unknown impurity -III ≤0.10 % |
|
|
Total impurities ≤1.00 % |
|
|
Optical rotation (on as is basis) (10mg/ml in N,Ndimethylformamide) |
-110.0° ~ -115.0° |
|
Water content (by KF) |
≤4.0% |
|
Residual solvents (by GC) |
Acetone ≤1000ppm (In-house) |
|
Di-isopropyl ether ≤100ppm (In-house) |
|
|
Ethyl ether ≤5000ppm |
|
|
Acetonitrile ≤410ppm |
|
|
Toluene ≤890ppm |
|
|
Hexane ≤290ppm |
|
|
Microbial test (in house) |
Total aerobic microbial count ≤100cfu/gm |
|
Total yeast and mould count ≤10cfu/gm |
|
|
Specified organisms (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) should absent |
|
|
Assay (by HPLC) (on anhydrous and solvent free basis) |
98%~102% |
Product detail pictures:
Related Product Guide:
We have advanced equipment. Our products are exported to the USA, the UK and so on, enjoying a good reputation among customers for Fixed Competitive Price 112828-00-9 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore , The product will supply to all over the world, such as: Costa Rica, New Delhi, Angola, Please feel cost-free to send us your specifications and we'll respond to you asap. We've got a professional engineering team to serve for the every single detailed needs. Free samples may be sent for you personally to know far more facts. So that you can meet your desires, please really feel cost-free to contact us. You could send us emails and call us straight. Additionally, we welcome visits to our factory from all over the world for much better recognizing of our corporation. nd merchandise. In our trade with merchants of several countries, we often adhere to the principle of equality and mutual advantage. It is our hope to market, by joint efforts, both trade and friendship to our mutual benefit. We look forward to getting your inquiries.
By Genevieve from Thailand - 2018.12.05 13:53
The supplier cooperation attitude is very good, encountered various problems, always willing to cooperate with us, to us as the real God.
By Elaine from Leicester - 2017.03.28 12:22
