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Fixed Competitive Price 112828-00-9 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore

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With reliable good quality system, great standing and perfect consumer support, the series of products and solutions produced by our organization are exported to quite a few countries and regions for Tacrolimus monohydrate 109581-93-3, 24729-96-2, Hesperidin Mixture 90:10, Be sure to never wait to get in touch with us for anyone who is interested within our solutions. We firmly believe that our products and solutions will make you happy.
Fixed Competitive Price 112828-00-9 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore Detail:

Payment: T/T, L/C
Product Origin: China
Shipping Port: Beijing/Shanghai/Hangzhou
Production capacity: 1kg/month
Order(MOQ): 1g
Lead Time: 3 Working Days
Storage condition: Stored in cool, dry place, room temperature.
Package material: vial, bottle
Package size: 1g/vial, 5/vial, 10g/vial, 50g/bottle, 500g/bottle
Safety information:  UN 2811 6.1/PG 3

Tacrolimus monohydrate

Introduction

Tacrolimus, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. It can be used to treat dry eye syndrome in cats and dogs.

Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, as part of the body’s learned (or adaptive) immune response.

Specification (USP43)

Item

Specification

Appearance

White or almost white crystalline powder

Identification

IR, HPLC

Solubility

Very soluble in methanol, freely soluble in N,N dimethylformamide and in alcohol, practically in soluble in water.

Residue on ignition

≤0.10 %

Organic impurities

 (procedure-2)

Ascomycin 19-epimer ≤0.10 %

Ascomycin ≤0.50 %

Desmethyl tacrolimus ≤0.10 %

Tacrolimus 8-epimer ≤0.15 %

Tacrolimus 8-propyl analog ≤0.15 %

Unknown impurity -I ≤0.10 %

Unknown impurity -II ≤0.10 %

Unknown impurity -III ≤0.10 %

Total impurities ≤1.00 %

Optical rotation (on as is basis)

 (10mg/ml in N,Ndimethylformamide)

-110.0° ~ -115.0°

Water content (by KF)

≤4.0%

Residual solvents (by GC)

Acetone ≤1000ppm (In-house)

Di-isopropyl ether ≤100ppm (In-house)

Ethyl ether ≤5000ppm

Acetonitrile ≤410ppm

Toluene ≤890ppm

Hexane ≤290ppm

Microbial test (in house)

Total aerobic microbial count ≤100cfu/gm

Total yeast and mould count ≤10cfu/gm

Specified organisms (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) should absent

Assay (by HPLC) (on anhydrous and solvent free basis)

98%~102%


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Fixed Competitive Price 112828-00-9 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore detail pictures


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  • The accounts manager made a detailed introduction about the product, so that we have a comprehensive understanding of the product, and ultimately we decided to cooperate.
    5 Stars By Rosalind from Finland - 2017.10.13 10:47
    This supplier offers high quality but low price products, it is really a nice manufacturer and business partner.
    5 Stars By Barbara from Berlin - 2018.02.12 14:52