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Hot sale Spironolactone 52-01-7 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore

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Hot sale Spironolactone 52-01-7 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore Detail:

Payment: T/T, L/C
Product Origin: China
Shipping Port: Beijing/Shanghai/Hangzhou
Production capacity: 1kg/month
Order(MOQ): 1g
Lead Time: 3 Working Days
Storage condition: Stored in cool, dry place, room temperature.
Package material: vial, bottle
Package size: 1g/vial, 5/vial, 10g/vial, 50g/bottle, 500g/bottle
Safety information:  UN 2811 6.1/PG 3

Tacrolimus monohydrate

Introduction

Tacrolimus, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. It can be used to treat dry eye syndrome in cats and dogs.

Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, as part of the body’s learned (or adaptive) immune response.

Specification (USP43)

Item

Specification

Appearance

White or almost white crystalline powder

Identification

IR, HPLC

Solubility

Very soluble in methanol, freely soluble in N,N dimethylformamide and in alcohol, practically in soluble in water.

Residue on ignition

≤0.10 %

Organic impurities

 (procedure-2)

Ascomycin 19-epimer ≤0.10 %

Ascomycin ≤0.50 %

Desmethyl tacrolimus ≤0.10 %

Tacrolimus 8-epimer ≤0.15 %

Tacrolimus 8-propyl analog ≤0.15 %

Unknown impurity -I ≤0.10 %

Unknown impurity -II ≤0.10 %

Unknown impurity -III ≤0.10 %

Total impurities ≤1.00 %

Optical rotation (on as is basis)

 (10mg/ml in N,Ndimethylformamide)

-110.0° ~ -115.0°

Water content (by KF)

≤4.0%

Residual solvents (by GC)

Acetone ≤1000ppm (In-house)

Di-isopropyl ether ≤100ppm (In-house)

Ethyl ether ≤5000ppm

Acetonitrile ≤410ppm

Toluene ≤890ppm

Hexane ≤290ppm

Microbial test (in house)

Total aerobic microbial count ≤100cfu/gm

Total yeast and mould count ≤10cfu/gm

Specified organisms (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) should absent

Assay (by HPLC) (on anhydrous and solvent free basis)

98%~102%


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Hot sale Spironolactone 52-01-7 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore detail pictures


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"Control the standard by the details, show the power by quality". Our business has strived to establish a highly efficient and stable team staff and explored an effective good quality regulate course of action for Hot sale Spironolactone 52-01-7 - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore , The product will supply to all over the world, such as: Jakarta, Frankfurt, Orlando, Our mission is "Provide Products with Reliable Quality and Reasonable Prices". We welcome customers from every corner of the world to contact us for future business relationships and achieving mutual success!
  • The product classification is very detailed that can be very accurate to meet our demand, a professional wholesaler.
    5 Stars By Daisy from Italy - 2018.02.04 14:13
    Good quality, reasonable prices, rich variety and perfect after-sales service, it's nice!
    5 Stars By Martin Tesch from venezuela - 2018.05.15 10:52