China Renewable Design for 149394-66-1 - Posaconazole 171228-49-2 Antibiotic – Neore manufacturers and suppliers

Renewable Design for 149394-66-1 - Posaconazole 171228-49-2 Antibiotic – Neore

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Renewable Design for 149394-66-1 - Posaconazole 171228-49-2 Antibiotic – Neore Detail:

Payment: T/T, L/C
Product Origin: China
Shipping Port: Beijing/Shanghai/Hangzhou
Production capacity: 20kg/month
Order(MOQ): 10g
Lead Time: 3 Working Days
Storage condition: Stored in cool, dry place, room temperature.
Package material: vial
Package size: 10g/vial
Safety information: Not dangerous goods

Posaconazole

Introduction

Posaconazole is a triazole antifungal medication.
Posaconazole is used to treat invasive Aspergillus and Candida infections. It is also used for the treatment of oropharyngeal candidiasis (OPC), including OPC refractory to itraconzaole and/or fluconazole therapy.
It is also used to treat invasive infections by Candida, Mucor, and Aspergillus species in severely immunocompromised patients.

Specification (in house standard)

Item	Specification
Appearance	White or almost white, hygroscopic powder

Item	Specification
Appearance	White or off-white crystalline powder
Specific rotation	-28.0°~-34.0°
Crystal form	It should be crystalline Ⅰ, with 2-theta angles of 14.4±0.2°,19.2±0.2°,21.7±0.2°,24.3±0.2°29.3±0.2°
Identification	IR, HPLC
Related substances I	PO-R1 NMT 0.10%
	PO-R2 NMT 0.10%
	PO-R3 NMT 0.10%
	PO-R4 NMT 0.10%
	PO-D3 & PO-D5 NMT 0.10%
	PO-D7 & PO-D10 NMT 0.10%
	Each of unspecified impurity NMT 0.10%
	Total impurities NMT 0.5%
Related substances Ⅱ	PO-E NMT 0.10%
	PO-D1 NMT 0.10%
	PO-R5 NMT 0.10%
Residual solvents	Methanol NMT 3000ppm
	Ethanol NMT 5000ppm
	Dichloromethane NMT 600ppm
	Tetrahydrofuran NMT 720ppm
	N, N-dimethyl formamide NMT 880ppm
	Triethylamine NMT 100ppm
	Dimethy sulfoxide NMT 5000ppm
Water	NMT 2.0%
Residue on ignition	NMT 0.1%
Heavy metals	NMT 10ppm
Microbial limit	Total aerobic NMT 1000cfu/g Total yeasts and molds NMT 100cfu/g E.coli should be absent
Assay	98.0%-102.0%(on anhydrous basis)
Assay	98.0%-102.0%(on anhydrous and solvents free basis)

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